A 34-year-old patient presented with giant, transient urticarial skin lesions and periorbital edema after a 3-month stay in DR Congo. Retrospective analysis of stored samples revealed that these signs were prodromal manifestations of acute hepatitis B infection. The hepatitis B infection was spontaneously cleared; the skin lesion did not recur.

doi.org/10.1111/j.1708-8305.2011.00507.x, hdl.handle.net/1765/34270
Journal of travel medicine
Erasmus MC: University Medical Center Rotterdam

van Aalsburg, R., de Pagter, A., & van Genderen, P. (2011). Urticaria and periorbital edema as prodromal presenting signs of acute hepatitis B infection. Journal of travel medicine, 18(3), 224–225. doi:10.1111/j.1708-8305.2011.00507.x