Induction and characterization of monoclonal anti-idiotypic antibodies reactive with idiotopes of canine parvovirus neutralizing monoclonal antibodies.
Veterinary Immunology and Immunopathology , Volume 29 - Issue 1-2 p. 139- 150
Monoclonal anti-idiotypic (anti-Id) antibodies (Ab2) were generated against idiotypes (Id) of canine parvovirus (CPV) specific monoclonal antibodies (MoAbs). The binding of most of these anti-Id antibodies to their corresponding Id could be inhibited by antigen, thus classifying these anti-Id antibodies as Ab2 gamma or Ab2 beta. By inhibiting experiments it was shown that these anti-Id antibodies did not recognize interspecies cross-reactive idiotopes, but recognized private idiotopes, uniquely associated with the Id of the anti-CPV MoAb used for immunization. This classifies these anti-Id antibodies as non-internal image Ab2 gamma. The potential use of these non-internal image anti-Id antibodies for the induction of antiviral antibodies in the CPV system is discussed.
|, , , , , , , , , , , , , , , , , , , , ,|
|Veterinary Immunology and Immunopathology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Rimmelzwaan, G.F, van Es, J, Drost, G.A, Uytdehaag, F.G.C.M, & Osterhaus, A.D.M.E. (1991). Induction and characterization of monoclonal anti-idiotypic antibodies reactive with idiotopes of canine parvovirus neutralizing monoclonal antibodies. Veterinary Immunology and Immunopathology, 29(1-2), 139–150. doi:10.1016/0165-2427(91)90059-L