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F. UytdeHaag, R.W.J. van der Heijden (Roger) and A.D.M.E. Osterhaus (Albert)

1991-12-01

Maintenance of immunological memory: A role for CD5+ B cells?

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Publication

Immunology Today , Volume 12 - Issue 12 p. 439- 442

How memory is retained is an immunological mystery. One possibility, argued here by Fons UytdeHaag and colleagues, is that memory is imprinted in the somatically-mutated Ig expressed by certain CD5+ B cells. The theory proposes that the Ig expressed by this self-renewing population acts as surrogate antigen, selecting and stimulating emerging antigen-specific lymphocytes.

Additional Metadata
Keywords *Antigens, CD, *Gene Rearrangement, B-Lymphocyte, *Immunologic Memory, 0 (Antibodies, Anti-Idiotypic), 0 (Antigens, CD), 0 (Antigens, CD5), 0 (Immunoglobulin Variable Region), 0 (Immunoglobulins, Heavy-Chain), 0 (Immunoglobulins, Light-Chain), 0 (Immunoglobulins, Surface), Animals, Antibodies, Anti-Idiotypic/genetics/immunology, Antigens, CD5, B-Lymphocyte Subsets/*immunology, Genes, Immunoglobulin, Hematopoietic Stem Cells/immunology, Human, Immunoglobulin Variable Region/genetics, Immunoglobulins, Heavy-Chain/genetics, Immunoglobulins, Light-Chain/genetics, Immunoglobulins, Surface/genetics/*immunology, Mice, Models, Biological, Mutation, Plasma Cells/immunology, Support, Non-U.S. Gov't
Persistent URL doi.org/10.1016/0167-5699(91)90016-M, hdl.handle.net/1765/3430
Journal Immunology Today
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
UytdeHaag, F., van der Heijden, R., & Osterhaus, A. (1991). Maintenance of immunological memory: A role for CD5+ B cells?. Immunology Today, 12(12), 439–442. doi:10.1016/0167-5699(91)90016-M
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