A 26-year-old male experienced a recurrence of idiopathic focal segmental glomerulosclerosis (iFSGS) after his second renal transplant. Reduction of proteinuria was rapidly induced by plasmapheresis (PP) and the patient has remained in remission with a once-weekly PP regimen, which has now been continued for >3 years. We were also able to induce remission of iFSGS in this patient by treatment with high cut-off haemodialysis using the Theralite™ dialyser. This observation lends support for the pathophysiological role of an as yet unknown, circulating glomerular filtration barrier permeability factor with an estimated weight of between 30 and 50 kDa.

Additional Metadata
Keywords focal segmental glomerulosclerosis, plasmapheresis, proteinuria, transplantation
Persistent URL dx.doi.org/10.1093/ndtplus/sfr084, hdl.handle.net/1765/34575
Journal N D T Plus
Citation
Noorlander, I, Hesselink, D.A, Wabbijn, M, & Betjes, M.G.H. (2011). High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis. N D T Plus, 4(5), 321–323. doi:10.1093/ndtplus/sfr084