A 26-year-old male experienced a recurrence of idiopathic focal segmental glomerulosclerosis (iFSGS) after his second renal transplant. Reduction of proteinuria was rapidly induced by plasmapheresis (PP) and the patient has remained in remission with a once-weekly PP regimen, which has now been continued for >3 years. We were also able to induce remission of iFSGS in this patient by treatment with high cut-off haemodialysis using the Theralite™ dialyser. This observation lends support for the pathophysiological role of an as yet unknown, circulating glomerular filtration barrier permeability factor with an estimated weight of between 30 and 50 kDa.

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doi.org/10.1093/ndtplus/sfr084, hdl.handle.net/1765/34575
N D T Plus
Erasmus MC: University Medical Center Rotterdam

Noorlander, I., Hesselink, D., Wabbijn, M., & Betjes, M. (2011). High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis. N D T Plus, 4(5), 321–323. doi:10.1093/ndtplus/sfr084