Objectives: We compared the 5-year outcomes of diabetic patients with multivessel disease treated with sirolimus-eluting stents (SES), bare-metal stents (BMS), and coronary artery bypass graft surgery (CABG) enrolled in the ARTS (Arterial Revascularization Therapy Study) I and II studies. Background: Diabetes is an established risk factor for major adverse cardiac events after revascularization. Recent trials suggest that revascularization with drug-eluting stents has equivalent safety to CABG up to 2 years. Methods: The ARTS I and II studies included 367 diabetic patients (SES: 159, CABG: 96, and BMS: 112) compared with respect to 5-year clinical outcomes. Results: The rate of major adverse cardiovascular and cerebrovascular events was significantly higher in patients treated with BMS (BMS 53.6% vs. CABG 23.4% vs. SES 40.5%; log-rank, p < 0.01 for SES vs. BMS and SES vs. CABG). There was no significant difference in mortality among all 3 groups. There was, however, a statistically significant difference in the myocardial infarction rate between BMS and CABG arms (BMS 11.0%, CABG 5.2%, SES 4.8%, p = 0.04 for SES vs. BMS and p = 0.76 for SES vs. CABG). The rate of repeat revascularization was significantly lower in patients treated with CABG compared with SES (SES 33.2% vs. CABG 10.7%, p < 0.001). Revascularization rate of patients treated with SES at 5 years approached that of patients treated with BMS although remained significantly lower. This "catch-up" phenomenon was not apparent in the nondiabetic population. Conclusions: At 5-year follow-up, CABG has comparable safety and superior efficacy compared with BMS and SES in the treatment of diabetic patients with multivessel disease.

bare-metal stent(s) (BMS), coronary artery bypass graft (CABG), diabetes, drug-eluting stent(s) (DES), multivessel disease (MVD)
dx.doi.org/10.1016/j.jcin.2010.12.004, hdl.handle.net/1765/34685
JACC: Cardiovascular Interventions
Erasmus MC: University Medical Center Rotterdam

Onuma, Y, Wykrzykowska, J.J, Garg, S.A, & Serruys, P.W.J.C. (2011). 5-year follow-up of coronary revascularization in diabetic patients with multivessel coronary artery disease: Insights from ARTS (Arterial revascularization therapy study)-II and ARTS-I trials. JACC: Cardiovascular Interventions, 4(3), 317–323. doi:10.1016/j.jcin.2010.12.004