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P. Kolovos (Petros), T.A. Knoch (Tobias), F.G. Grosveld (Frank), P.R. Cook (Peter) and A. Papantonis (Argyris)

2012-01-10

Enhancers and silencers: An integrated and simple model for their function

Publication

Publication

Epigenetics & Chromatin , Volume 5 - Issue 1

Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function is proposed. All are transcription units that tether their target promoters close to, or distant from, transcriptional hot spots (or 'factories').

Additional Metadata
Keywords chromosome conformation capture, enhancer, hub, insulator, long-range interactions, silencer, three-dimensional genome architecture, transcription factory
Persistent URL doi.org/10.1186/1756-8935-5-1, hdl.handle.net/1765/35010
Journal Epigenetics & Chromatin
Grant This work was funded by the European Commission 7th Framework Programme; grant id fp7/291728 - Development and Coordination of Synthetic Biology in the European Research Area (ERASYNBIO), This work was funded by the European Commission 7th Framework Programme; grant id fp7/211727 - Enabling Desktop Grids for e-Science (EDGES)
Organisation Biophysical Genomics, Department Cell Biology & Genetics
Citation
Kolovos, P., Knoch, T., Grosveld, F., Cook, P., & Papantonis, A. (2012). Enhancers and silencers: An integrated and simple model for their function. Epigenetics & Chromatin (Vol. 5). doi:10.1186/1756-8935-5-1
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