Viral replication and development of specific immunity in macaques after infection with different measles virus strains.
The Journal of Infectious Diseases , Volume 70 p. 443- 448
Cynomolgus monkeys (Macaca fascicularis) were experimentally infected with a wild type measles virus (MV) strain (MV-BIL). Following intratracheal inoculation with different infectious doses, the virus could be isolated from peripheral blood mononuclear cells (PBMC), lung lavage cells, and pharyngeal cells. The kinetics of the cell-associated viremia was similar in all infected animals. They developed specific serum IgM, IgG, and neutralizing antibody responses as well as MV-specific T cell-mediated immunity. Monkeys infected intratracheally or intramuscularly with the wild type MV-Edmonston or the attenuated MV-Schwartz strain showed a lower level of PBMC-associated viremia and less pronounced specific IgM responses. Nine months after infection with MV strains, all of the monkeys were protected from intratracheal reinfection with MV-BIL. This monkey model is suitable for study of new generations of vaccines and vaccination strategies for measles.
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|The Journal of Infectious Diseases|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
van Binnendijk, R.S, van der Heijden, R.W.J, van Amerongen, G, Uytdehaag, F.G.C.M, & Osterhaus, A.D.M.E. (1994). Viral replication and development of specific immunity in macaques after infection with different measles virus strains. The Journal of Infectious Diseases, 70, 443–448. Retrieved from http://hdl.handle.net/1765/3503