Objective: To determine whether further histologic assessment can be omitted after office sampling produced a nondiagnostic specimen. Methods: Data were retrieved from a prospective cohort study of 913 women presenting with postmenopausal bleeding. This study was limited to women with an endometrial thickness either 5 mm or greater or that could not be measured, and in whom an endometrial biopsy performed in the office yielded nondiagnostic results. Results: Endometrial thickness was nonreassuring or unknown in 516 women, of whom 403 (78.1%) underwent office endometrial sampling. In 66 women the amount of tissue obtained was not sufficient for pathologic characterization. Further investigation revealed an endometrial malignancy in 3 of these 66 women and atypical hyperplasia in 1. Conclusion: In women with postmenopausal bleeding and a nonreassuring transvaginal ultrasound evaluation, a nondiagnostic office endometrial sample does not rule out endometrial cancer and further endometrial sampling is advisable.

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doi.org/10.1016/j.ijgo.2007.05.040, hdl.handle.net/1765/35125
International Journal of Gynecology & Obstetrics
Erasmus MC: University Medical Center Rotterdam

van Doorn, L., Opmeer, B., Burger, C., Duk, J., Kooi, S., & Mol, B. (2007). Inadequate office endometrial sample requires further evaluation in women with postmenopausal bleeding and abnormal ultrasound results. International Journal of Gynecology & Obstetrics, 99(2), 100–104. doi:10.1016/j.ijgo.2007.05.040