Objective: To determine whether further histologic assessment can be omitted after office sampling produced a nondiagnostic specimen. Methods: Data were retrieved from a prospective cohort study of 913 women presenting with postmenopausal bleeding. This study was limited to women with an endometrial thickness either 5 mm or greater or that could not be measured, and in whom an endometrial biopsy performed in the office yielded nondiagnostic results. Results: Endometrial thickness was nonreassuring or unknown in 516 women, of whom 403 (78.1%) underwent office endometrial sampling. In 66 women the amount of tissue obtained was not sufficient for pathologic characterization. Further investigation revealed an endometrial malignancy in 3 of these 66 women and atypical hyperplasia in 1. Conclusion: In women with postmenopausal bleeding and a nonreassuring transvaginal ultrasound evaluation, a nondiagnostic office endometrial sample does not rule out endometrial cancer and further endometrial sampling is advisable.

Endometrial cancer, Endometrial thickness, Nondiagnostic sample, Office endometrial sampling, Transvaginal sonography
dx.doi.org/10.1016/j.ijgo.2007.05.040, hdl.handle.net/1765/35125
International Journal of Gynecology & Obstetrics
Erasmus MC: University Medical Center Rotterdam

van Doorn, H.C, Opmeer, B.C, Burger, C.W, Duk, M.J, Kooi, G.S, & Mol, B.W.J. (2007). Inadequate office endometrial sample requires further evaluation in women with postmenopausal bleeding and abnormal ultrasound results. International Journal of Gynecology & Obstetrics, 99(2), 100–104. doi:10.1016/j.ijgo.2007.05.040