High innate production capacity of tumor necrosis factor-α and decline of handgrip strength in old age

Taekema, Diana; Westendorp, Rudi; Frölich, Marijke; Gussekloo, Jacobijn

doi:10.1016/j.mad.2007.07.001

D.G. Taekema (Diana), R.G.J. Westendorp (Rudi), M. Frölich (Marijke) and J. Gussekloo (Jacobijn)

2007-09-01

High innate production capacity of tumor necrosis factor-α and decline of handgrip strength in old age

Mechanisms of Ageing and Development , Volume 128 - Issue 9 p. 517- 521

Increased signaling of the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) elicits apoptosis of skeletal muscle cells in various animal models. Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-α precedes a steeper decline in muscle strength over time.

Additional Metadata
Keywords	Cytokine production capacity, Elderly people, Handgrip strength, Human, Inflammation, Muscle weakness, TNF-α
Persistent URL	doi.org/10.1016/j.mad.2007.07.001, hdl.handle.net/1765/35214
Journal	Mechanisms of Ageing and Development
Organisation	Erasmus MC: University Medical Center Rotterdam
Citation APA Style AAA Style APA Style Cell Style Chicago Style Harvard Style IEEE Style MLA Style Nature Style Vancouver Style American-Institute-of-Physics Style Council-of-Science-Editors Style BibTex Format Endnote Format RIS Format CSL Format DOIs only Format	Taekema, D., Westendorp, R., Frölich, M., & Gussekloo, J. (2007). High innate production capacity of tumor necrosis factor-α and decline of handgrip strength in old age. Mechanisms of Ageing and Development, 128(9), 517–521. doi:10.1016/j.mad.2007.07.001

High innate production capacity of tumor necrosis factor-α and decline of handgrip strength in old age

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