2007-07-01
PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome
Publication
Publication
Journal of Clinical Microbiology , Volume 45 - Issue 7 p. 2316- 2320
Molecular mimicry of Campylobacter jejuni lipooligosaccharides (LOS) by gangliosides in peripheral nerve tissue probably triggers the Guillain-Barré syndrome due to the induction of cross-reactive antibodies. PCR-restriction fragment length polymorphism analysis of C. jejuni genes involved in the biosynthesis of LOS demonstrated that specific genes were associated with the expression of ganglioside mimics and the development of neuropathy. Copyright
Additional Metadata | |
---|---|
doi.org/10.1128/JCM.00203-07, hdl.handle.net/1765/35340 | |
Journal of Clinical Microbiology | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Godschalk, P., van Belkum, A., van den Braak, N., van Netten, D., Ang, W., Gilbert, M., … Jacobs, B. (2007). PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome. Journal of Clinical Microbiology, 45(7), 2316–2320. doi:10.1128/JCM.00203-07 |