Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV-5 changed the susceptibility of the viruses to neutralizing antibody.

0 (Antibodies, Viral), 0 (Immune Sera), 0 (Membrane Glycoproteins), 0 (Viral Proteins), Animals, Antibodies, Viral/*immunology, Cell Line, Cloning, Molecular, Dogs, Immune Sera, Immunodeficiency Virus, Feline/*immunology, Membrane Glycoproteins/*immunology, Neutralization Tests, Point Mutation, Support, Non-U.S. Gov't, Viral Proteins/*immunology
Journal of Virology
Erasmus MC: University Medical Center Rotterdam

Siebelink, C.H.J, Huisman, W, Karlas, J.A, Rimmelzwaan, G.F, Bosch, M.L, & Osterhaus, A.D.M.E. (1995). Neutralization of feline immunodeficiency virus by polyclonal cat antibody: Simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein. Journal of Virology, 69, 5124–5127. Retrieved from