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C.H.J. Siebelink (Kees), W. Huisman (Willem), J.A. Karlas (Jos), G.F. Rimmelzwaan (Guus), M.L. Bosch (Marnix) and A.D.M.E. Osterhaus (Albert)

1995

Neutralization of feline immunodeficiency virus by polyclonal cat antibody: Simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein.

Publication

Publication

Journal of Virology , Volume 69 p. 5124- 5127

Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV-5 changed the susceptibility of the viruses to neutralizing antibody.

Additional Metadata
Keywords 0 (Antibodies, Viral), 0 (Immune Sera), 0 (Membrane Glycoproteins), 0 (Viral Proteins), Animals, Antibodies, Viral/*immunology, Cell Line, Cloning, Molecular, Dogs, Immune Sera, Immunodeficiency Virus, Feline/*immunology, Membrane Glycoproteins/*immunology, Neutralization Tests, Point Mutation, Support, Non-U.S. Gov't, Viral Proteins/*immunology
Persistent URL hdl.handle.net/1765/3545
Journal Journal of Virology
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Siebelink, C.H.J, Huisman, W, Karlas, J.A, Rimmelzwaan, G.F, Bosch, M.L, & Osterhaus, A.D.M.E. (1995). Neutralization of feline immunodeficiency virus by polyclonal cat antibody: Simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein. Journal of Virology, 69, 5124–5127. Retrieved from http://hdl.handle.net/1765/3545
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