Objective: To provide an overview of invasive prenatal diagnosis in the Netherlands and to analyse trends. Methods: Annual results from all centres for invasive prenatal diagnosis in the Netherlands over the period 1991-2000 were combined and described, with particular emphasis on indications, abnormal results, type of invasive procedures, and terminations of pregnancy. Results: The percentage of invasive prenatal diagnosis increased from 5% of births in 1991 to 6% in 1996 and subsequently remained at that level. During the study period, the number of pregnant women aged 36 and older increased by 70%, but the number of procedures performed because of maternal age remained stable. The detection rate for abnormal results was 2-3% for maternal age and rose from 9 to 13% for other indications. Other trends during the study period included a relative decrease in cordocentesis (-82%) and chorionic villi biopsy (-18%) in favour of amniocentesis (+48%), and a strong decrease in the number of amniocentesis procedures for increased risk of neural tube defect. In 71% of the cases with abnormal results, the pregnancy was terminated. Conclusion: There was a significant decrease in the percentage of pregnant women aged 36 or older who underwent invasive prenatal diagnosis without previous screening. Copyright

Amniocentesis, Chorionic villi biopsy, Prenatal diagnosis, Termination of pregnancy
dx.doi.org/10.1002/pd.1659, hdl.handle.net/1765/35837
Prenatal Diagnosis
Erasmus MC: University Medical Center Rotterdam

Nagel, H.T.C, Knegt, A.C, Kloosterman, M.D, Wildschut, H.I.J, Leschot, N.J, & Vandenbussche, F.P.H.A. (2007). Prenatal diagnosis in the Netherlands, 1991-2000: Number of invasive procedures, indications, abnormal results and terminations of pregnancy. Prenatal Diagnosis, 27(3), 251–257. doi:10.1002/pd.1659