Objective: To provide an overview of invasive prenatal diagnosis in the Netherlands and to analyse trends. Methods: Annual results from all centres for invasive prenatal diagnosis in the Netherlands over the period 1991-2000 were combined and described, with particular emphasis on indications, abnormal results, type of invasive procedures, and terminations of pregnancy. Results: The percentage of invasive prenatal diagnosis increased from 5% of births in 1991 to 6% in 1996 and subsequently remained at that level. During the study period, the number of pregnant women aged 36 and older increased by 70%, but the number of procedures performed because of maternal age remained stable. The detection rate for abnormal results was 2-3% for maternal age and rose from 9 to 13% for other indications. Other trends during the study period included a relative decrease in cordocentesis (-82%) and chorionic villi biopsy (-18%) in favour of amniocentesis (+48%), and a strong decrease in the number of amniocentesis procedures for increased risk of neural tube defect. In 71% of the cases with abnormal results, the pregnancy was terminated. Conclusion: There was a significant decrease in the percentage of pregnant women aged 36 or older who underwent invasive prenatal diagnosis without previous screening. Copyright

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doi.org/10.1002/pd.1659, hdl.handle.net/1765/35837
Prenatal Diagnosis
Erasmus MC: University Medical Center Rotterdam

Nagel, H.T.C, Knegt, A.C, Kloosterman, M.D, Wildschut, H.I.J, Leschot, N.J, & Vandenbussche, F.P.H.A. (2007). Prenatal diagnosis in the Netherlands, 1991-2000: Number of invasive procedures, indications, abnormal results and terminations of pregnancy. Prenatal Diagnosis, 27(3), 251–257. doi:10.1002/pd.1659