Anti-Yo-associated paraneoplastic cerebellar degeneration is a cancer-related syndrome affecting the nervous system. This syndrome occurs almost exclusively in middle-aged women with gynecological cancers and it is rarerly found in patients with other types of cancer or in males. In this report we describe a male patient adenocarcinoma of the gastroesophageal junction and PCD with anti-Yo antibodies. To our knowledge, this is only the third report of PCD with positive anti-Yo antibodies in an esophageal tumor and the first report in a tumor of the gastroesophageal junction. Copyright

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Digestive Surgery
Erasmus MC: University Medical Center Rotterdam

Debes, J. D., Lagarde, S., Hulsenboom, E., Smitt, P., ten Kate, F., Sulter, G. A., & van Lanschot, J. (2007). Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with adenocarcinoma of the gastroesophageal junction. Digestive Surgery, 24(5), 395–397. doi:10.1159/000107782