2007-07-01
An overview of current microarray-based human globin gene mutation detection methods
Publication
Publication
Hemoglobin: international journal for hemoglobin research , Volume 31 - Issue 3 p. 289- 311
□ The panoply of human globin gene mutation detection methods could become significantly enriched with the advent of microarray-based genotyping platforms. The aim of this article is to provide an overview of the current medium and high-throughput microarray-based globin gene mutation detection platforms, namely the microelectronic array, the "thalassochip" arrayed primer extension (APEX) technology and the single base extension methods. This article also outlines an emerging method based on multiple ligation probe amplification (MLPA) and discusses the implications of customized solutions for resequencing of genomic loci in relation to molecular genetic testing of hemoglobinopathies. Copyright
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doi.org/10.1080/03630260701459366, hdl.handle.net/1765/36074 | |
Hemoglobin: international journal for hemoglobin research | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Cremonesi, L., Ferrari, M., Giordano, P. C., Harteveld, C., Kleanthous, M., Papasavva, T., … Traeger-Synodinos, J. (2007). An overview of current microarray-based human globin gene mutation detection methods. Hemoglobin: international journal for hemoglobin research (Vol. 31, pp. 289–311). doi:10.1080/03630260701459366 |