Purpose: The purpose of this study is to provide information about sexual function (SF) after three-dimensional conformal radiotherapy (3D-CRT) for prostate cancer while taking important factors into account that influence SF. Methods and Materials: Between June 1997 and February 2003, a total of 268 patients from a randomized dose-escalation trial comparing 68 Gy and 78 Gy agreed to participate in an additional part of the trial that evaluated SF. Results: At baseline 28% of patients had erectile dysfunction (ED). After 1 year, 27% of the pretreatment potent patients had developed ED. After 2 years this percentage had increased to 36%. After 3 years it almost stabilized at 38%. Satisfaction with sexual life was significantly correlated with ED. After 2 years one third of the pre-treatment potent patients still had considerable to very much sexual desire and found sex (very) important. No significant differences were found between the two dose-arms. Potency aids were used on a regular base by 14% of the patients. Conclusion: By taking adjuvant hormonal therapy (HT), HT during follow-up and potency aids into account, we found a lower percentage of ED after 3D-CRT than reported in previous prospective studies. A large group of patients still had sexual desire, considered sex important and 14% used potency aids after 3D-CRT.

Conformal radiotherapy, Dose-escalation, Erectile dysfunction, Prostate cancer, Sexual function
dx.doi.org/10.1016/j.ijrobp.2006.12.015, hdl.handle.net/1765/36083
International Journal of Radiation: Oncology - Biology - Physics
Erasmus MC: University Medical Center Rotterdam

van der Wielen, G.J, van Putten, W.L.J, & Incrocci, L. (2007). Sexual Function After Three-Dimensional Conformal Radiotherapy for Prostate Cancer: Results From a Dose-Escalation Trial. International Journal of Radiation: Oncology - Biology - Physics, 68(2), 479–484. doi:10.1016/j.ijrobp.2006.12.015