The first indication of flu activity in the Netherlands in the 1996/'97 season was the isolation of an A/H3N2 influenza virus in week 48 of 1996. In subsequent weeks influenza viruses were isolated sporadically. The clinical influenza activity increased from week I of 1997 and reached its peak in week 4 of 1997. Simultaneously with the increase of clinical influenza activity, an increasing number of influenza viruses were isolated. The epidemic had a relatively small extent. Initially, A/H3N2 influenza viruses were predominant, but in the second half of the epidemic an increasing number of influenza B viruses were isolated as well. The A/H3N2 viruses were antigenically fairly strongly distinct from the variants prevalent in the preceding years. This season influenza A/HINI viruses did not play a significant role and only one virus of this subtype was isolated. All influenza A/H3N2, A/HINI and B viruses isolated were antigenically similar to the vaccine strains.

*Influenza Vaccine, 0 (Antigens, Viral), 0 (Influenza Vaccine), Adolescent, Adult, Aged, Antigens, Viral, Child, Child, Preschool, English Abstract, Human, Influenza A Virus, Human/immunology/isolation & purification, Influenza B virus/immunology/isolation & purification, Influenza/*epidemiology/prevention & control/virology, Middle Aged, Orthomyxoviridae/immunology, Support, Non-U.S. Gov't
hdl.handle.net/1765/3609
Nederlands Tijdschrift voor Geneeskunde
Erasmus MC: University Medical Center Rotterdam

Rimmelzwaan, G.F, de Jong, J.C, Bartelds, A.I.M, Claas, E.C.J, van Wijngaarden, J.K, & Osterhaus, A.D.M.E. (1997). Influenza in het seizoen 1996/'97; vaccinsamenstelling voor het seizoen 1997/'98. Nederlands Tijdschrift voor Geneeskunde, 36, 1743–1747. Retrieved from http://hdl.handle.net/1765/3609