The first indication of flu activity in the Netherlands in the 1996/'97 season was the isolation of an A/H3N2 influenza virus in week 48 of 1996. In subsequent weeks influenza viruses were isolated sporadically. The clinical influenza activity increased from week I of 1997 and reached its peak in week 4 of 1997. Simultaneously with the increase of clinical influenza activity, an increasing number of influenza viruses were isolated. The epidemic had a relatively small extent. Initially, A/H3N2 influenza viruses were predominant, but in the second half of the epidemic an increasing number of influenza B viruses were isolated as well. The A/H3N2 viruses were antigenically fairly strongly distinct from the variants prevalent in the preceding years. This season influenza A/HINI viruses did not play a significant role and only one virus of this subtype was isolated. All influenza A/H3N2, A/HINI and B viruses isolated were antigenically similar to the vaccine strains.

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Nederlands Tijdschrift voor Geneeskunde
Erasmus MC: University Medical Center Rotterdam

Rimmelzwaan, G., de Jong, J., Bartelds, A., Claas, E., van Wijngaarden, J. K., & Osterhaus, A. (1997). Influenza in het seizoen 1996/'97; vaccinsamenstelling voor het seizoen 1997/'98. Nederlands Tijdschrift voor Geneeskunde, 36, 1743–1747. Retrieved from