Objectives: Eumycetoma caused by Madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required. Methods: MICs were determined for artemisinin and tea tree oil, two natural herbal compounds. Results: Artemisinin was not active against M. mycetomatis, but tea tree oil did inhibit its growth. Since tea tree oil's prime component easily penetrates the skin, tea tree oil could be a useful agent in the treatment of eumycetoma. Conclusions: Tea tree oil is active in vitro against M. mycetomatis.

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doi.org/10.1093/jac/dkl526, hdl.handle.net/1765/36122
Journal of Antimicrobial Chemotherapy
Erasmus MC: University Medical Center Rotterdam

van de Sande, W., Fahal, A., Riley, T., Verbrugh, H., & van Belkum, A. (2007). In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin. Journal of Antimicrobial Chemotherapy, 59(3), 553–555. doi:10.1093/jac/dkl526