In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin
Journal of Antimicrobial Chemotherapy , Volume 59 - Issue 3 p. 553- 555
Objectives: Eumycetoma caused by Madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required. Methods: MICs were determined for artemisinin and tea tree oil, two natural herbal compounds. Results: Artemisinin was not active against M. mycetomatis, but tea tree oil did inhibit its growth. Since tea tree oil's prime component easily penetrates the skin, tea tree oil could be a useful agent in the treatment of eumycetoma. Conclusions: Tea tree oil is active in vitro against M. mycetomatis.
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|Journal of Antimicrobial Chemotherapy|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
van de Sande, W.W.J, Fahal, A.H, Riley, T.V, Verbrugh, H.A, & van Belkum, A.F. (2007). In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin. Journal of Antimicrobial Chemotherapy, 59(3), 553–555. doi:10.1093/jac/dkl526