Prothrombotic coagulation abnormalities were analyzed in patients with untreated multiple myeloma. Increases in factor VIII, in von Willebrand factor and a decrease in protein S were observed and these changes Avere strongly associated with disease stage. No difference in baseline coagulation parameters was found between patients with and without subsequent venous thromboembolism.

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Erasmus MC: University Medical Center Rotterdam

Verduijn, M., Verduijn, M., Verduijn, M., & Verduijn, M. (2007). Prothrombotic coagulation abnormalities in patients with newly diagnosed multiple myeloma. Haematologica, 92(2), 279–280. doi:10.3324/haematol.10454