Genetic variation in thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with the risk of splanchnic vein thrombosis
Splanchnic vein thrombosis (SVT) has been associated with a hypercoagulable state. Thrombin-activatable fibrinolysis inhibitor (TAFI) may contribute to a hypercoagulable state, and therefore we were interested in the role of TAFI in SVT. Since the disease is frequently associated with liver insufficiency, which affects plasma levels of TAFI, we studied the role of variation in the TAFI gene in SVT. In a multicenter case-control study on 118 patients with SVT (39 Budd-Chiari syndrome and 85 portal vein thrombosis) and 118 population-based controls, the relationship of SVT with single nucleotide polymorphisms (SNPs) and haplotypes in the TAR gene (- 438G/A, Ala I47Thr, Thr3251le and 1583A/T) was determined.The risk for SVT was decreased (OR 0.2, 95% Cl 0. 1-0.7) in 147Thr/Thr homozygotes and slightly, but not significantly, increased in carriers of the 3251le allele (OR 1.6, 95%Cl 0.9-2.7). Haplotype analysis confirmed that the Ala 147Thr SNP has the strongest association with risk of SVT. In conclusion, genetic variation in the TAR gene is associated with risk of SVT, suggesting a role for TAFI in the pathogenetic mechanism of SVT.
|Keywords||Budd-Chiari syndrome, Fibrinolysis, Inflammation, Portal vein thrombosis, Single nucleotide polymorphism, Splanchnic vein thrombosis, Thrombin-activatable fibrinolysis inhibitor|
|Persistent URL||dx.doi.org/10.1160/TH06-07-0407, hdl.handle.net/1765/36142|
|Journal||Thrombosis and Haemostasis: international journal for vascular biology and medicine|
de Bruijne, E.L.E, Darwish Murad, S, de Maat, M.P.M, Tanck, M.W.T, Haagsma, E.B, van Hoek, B, … Leebeek, F.W.G. (2007). Genetic variation in thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with the risk of splanchnic vein thrombosis. Thrombosis and Haemostasis: international journal for vascular biology and medicine, 97(2), 181–185. doi:10.1160/TH06-07-0407