A facemask on a valved holding chamber (VHC) facilitates the inhalation of aerosols from metered dose inhalers (MDI) for young children. Only recently the facemask has been recognized as a vital part for efficient aerosol delivery. Several in vitro and in vivo studies show that a tight seal of the facemask is crucial for optimal aerosol deposition to the lungs. Even a small leak can reduce the dose delivered to the lungs considerably. However, a tight seal is difficult to obtain when a child is not cooperative. Depending on the design of the facemask, it is easier to obtain a good seal. Factors such as dead space, shape, and material should be considered when designing a facemask. However, when a child is upset and not cooperative during the administration, aerosol deposition will be minimal, even with the best-designed facemask.

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doi.org/10.1089/jam.2007.0578, hdl.handle.net/1765/36284
Journal of Aerosol Medicine
Erasmus MC: University Medical Center Rotterdam

Janssens, H., & Tiddens, H. (2007). Facemasks and aerosol delivery by metered dose inhaler-valved holding chamber in young children: A tight seal makes the difference. Journal of Aerosol Medicine, 20(SUPPL. 1). doi:10.1089/jam.2007.0578