Cerebellar LTD and Pattern Recognition by Purkinje Cells
Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied the LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model. With simple-spike firing as observed in vivo, the presentation of a pattern resulted in a burst of spikes followed by a pause. Surprisingly, the best criterion to distinguish learned patterns was the duration of this pause. Moreover, our simulations predicted that learned patterns elicited shorter pauses, thus increasing Purkinje-cell output. We tested this prediction in Purkinje-cell recordings both in vitro and in vivo. In vitro, we found a shortening of pauses when decreasing the number of active PFs or after inducing LTD. In vivo, we observed longer pauses in LTD-deficient mice. Our results suggest a novel form of neural coding in the cerebellar cortex.
|Keywords||MOLNEURO, SYSBIO, SYSNEURO|
|Persistent URL||dx.doi.org/10.1016/j.neuron.2007.03.015, hdl.handle.net/1765/36289|
Steuber, V, Mittmann, W, Hoebeek, F.E, Silver, R.A, de Zeeuw, C.I, Häusser, M, & de Schutter, E. (2007). Cerebellar LTD and Pattern Recognition by Purkinje Cells. Neuron, 54(1), 121–136. doi:10.1016/j.neuron.2007.03.015