Objective: To assess the effect of weight loss on the plasma lipid and remnant-like lipoprotein cholesterol (RLPc) response to a high-fat or a high-carbohydrate meal in a population of obese women. Design: Nutritional intervention study. Subjects: Sixteen obese women (mean body mass index (BMI): 37.6 ± 5 kg/m2). Methods: Subjects were asked to follow an energy-restricted diet (800 kcal/day) for 7 weeks, followed by a 1-week maintenance diet. Before and after weight loss, each participant was given (in random order) two iso-energetic meals containing either 80% fat and 20% protein (the high-fat meal) or 80% carbohydrate and 20% protein (the high-carbohydrate meal). Blood samples were collected over the following 10-h period. A two-way analysis of variance with repeated measures was used to assess the effect of the meal and postprandial time on biological variables and postprandial responses (notably RLPc levels). Results: Weight loss was associated with a significant decrease in fasting triglyceride (P = 0.0102), cholesterol (P < 0.0001), low-density lipoprotein cholesterol (P = 0.0003), high-density lipoprotein-cholesterol (P = 0.0009) and RLPc (P = 0.0015) levels. The triglyceride response to the high-fat meal was less intense after weight reduction than before (interaction P < 0.002). This effect persisted after adjustment on baseline triglyceride levels. The triglyceride response to the high-carbohydrate meal was biphasic (i.e. with two peaks, 1 and 6 h after carbohydrate intake). After adjustment on baseline values, weight reduction was associated with a trend towards a reduction in the magnitude of the second triglyceride peak (interaction P < 0.054). In contrast, there was no difference in postprandial RLPc responses before and after weight loss, again after adjustment on baseline levels. Conclusion: Our data suggest that weight loss preferentially affects postprandial triglyceride metabolism.

doi.org/10.1038/sj.ejcn.1602603, hdl.handle.net/1765/36452
European Journal of Clinical Nutrition
Erasmus MC: University Medical Center Rotterdam

Dallongeville, J., Gruson, E., Dallinga-Thie, G., Pigeyre, M., Gomila, S., & Romon, M. (2007). Effect of weight loss on the postprandial response to high-fat and high-carbohydrate meals in obese women. European Journal of Clinical Nutrition, 61(6), 711–718. doi:10.1038/sj.ejcn.1602603