Vaccine strategies to overcome maternal antibody mediated inhibition of measles vaccine. Presentation International Symposium on Immunity in Early Life, 17-19 November 1997, Veyrier-du-Lac, France.
Vaccine , Volume 16 - Issue 14-15 p. 1479- 1481
A vaccine that is effective in the presence of maternally derived virus neutralizing antibodies and can be administered successfully at an early age, would be favoured over the presently used live attenuated measles vaccines. With the advent of new molecular and immunological techniques, several options for the development of new generation vaccines, fulfilling these criteria, have arisen. We have recently evaluated the efficacy of recombinant vaccinia virus- and iscom-based candidate vaccines, presenting the F and H proteins of measles virus, in macaques with passively transferred virus neutralizing macaque antibodies. The data indicate that the further exploration of the potential of iscom based measles vaccines should be encouraged.
|maternal antibodies, measles, vaccines|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Osterhaus, A.D.M.E, van Amerongen, G, & van Binnendijk, R.S. (1998). Vaccine strategies to overcome maternal antibody mediated inhibition of measles vaccine. Presentation International Symposium on Immunity in Early Life, 17-19 November 1997, Veyrier-du-Lac, France. In Vaccine (Vol. 16, pp. 1479–1481). doi:10.1016/S0264-410X(98)00112-1