2007-05-01
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Publication
Publication
Nature Genetics , Volume 39 - Issue 5 p. 593- 595
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
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| doi.org/10.1038/ng2025, hdl.handle.net/1765/36655 | |
| Nature Genetics | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Lahortiga, I., de Keersmaecker, K., van Vlierberghe, P., Graux, C., Cauwelier, B., Lambert, F., Mentens, N., Beverloo, B., Pieters, R., Speleman, F., Odero, M., Bauters, M., Froyen, G., Marynen, P., Vandenberghe, P., Wlodarska, I., Meijerink, J.& Cools, J. (2007). Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nature Genetics, 39(5), 593–595.https://doi.org/10.1038/ng2025 |
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