2007-05-01
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Publication
Publication
Nature Genetics , Volume 39 - Issue 5 p. 593- 595
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
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| doi.org/10.1038/ng2025, hdl.handle.net/1765/36655 | |
| Nature Genetics | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Lahortiga, I., de Keersmaecker, K., van Vlierberghe, P., Graux, C., Cauwelier, B., Lambert, F., … Cools, J. (2007). Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nature Genetics, 39(5), 593–595. doi:10.1038/ng2025 |
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