Background: Mastocytosis is a disorder that can be subdivided into two forms: cutaneous and systemic. Patients with cutaneous mastocytosis only may suffer from cosmetic problems. Topical steroid application has been shown to be effective in cases of limited skin lesions. Methods: A case-controlled pilot study was conducted during a 6-weeks treatment using diluted 25% fluticasone propionate 0.05% cream under wet-wrap occlusion in 5 adults and 6 children. Improvement was measured up to the 24th week after treatment using the SCORMA Index. Results: The results of this pilot study showed a partial but clear cosmetic improvement in 9 of the 11 patients. The mean SCORMA Index decreased after treatment from 38 to 26. Conclusion: 25% dilution of fluticasone propionate 0.05% cream under wet-wrap occlusion is an alternative treatment modality for alleviating the symptoms of cutaneous mastocytosis, but the improvement may be moderate and fall short of the patient's expectations. Copyright

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doi.org/10.1159/000100885, hdl.handle.net/1765/36678
Dermatology: international journal for clinical and investigative dermatology
Erasmus MC: University Medical Center Rotterdam

Heide, R., de Waard-van der Spek, F., den Hollander, J., Tank, B., & Oranje, A. (2007). Efficacy of 25% diluted fluticasone propionate 0.05% cream as wet-wrap treatment in cutaneous mastocytosis. Dermatology: international journal for clinical and investigative dermatology, 214(4), 333–335. doi:10.1159/000100885