The association between Epstein-Barr virus subtype, human leukocyte antigen class I alleles, and the development of post-transplantation lymphoproliferative disorder was examined in a group of 25 bone marrow transplant recipients. A highly statistically significant correlation was observed between the human leukocyte antigen B51 allele and development of post-transplantation lymphoproliferative disorder (P = .0016). This study provides, to our knowledge, the first evidence that the human leukocyte antigen B51 allele might predispose bone marrow transplant recipients to Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder.

dx.doi.org/10.1086/511647, hdl.handle.net/1765/36690
Clinical Infectious Diseases
Erasmus MC: University Medical Center Rotterdam

Görzer, I, Puchhammer-Stöckl, E, van Esser, J.W.J, Niesters, H.G.M, & Cornelissen, J.J. (2007). Associations among Epstein-Barr virus subtypes, human leukocyte antigen class I alleles, and the development of posttransplantation lymphoproliferative disorder in bone marrow transplant recipients. Clinical Infectious Diseases, 44(5), 693–695. doi:10.1086/511647