The major developments in pig-to-non-human primate heart xenotransplantation during the past 20 years are summarized, largely through the experience of one investigator. Genetic modifications to organ-source pigs have been important steps in increasing heart xenograft survival from a few minutes in 1986 to 2 to 6 months in 2005.

doi.org/10.1016/j.healun.2006.12.005, hdl.handle.net/1765/36693
The Journal of Heart and Lung Transplantation
Erasmus MC: University Medical Center Rotterdam

Zhu, X, Dor, F.J.M.F, & Cooper, D.K.C. (2007). Pig-to-Non-human Primate Heart Transplantation: Immunologic Progress Over 20 Years. The Journal of Heart and Lung Transplantation (Vol. 26, pp. 210–218). doi:10.1016/j.healun.2006.12.005