2007
In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species
Publication
Publication
Microbes and Infection: a journal on infectious agents and host defenses , Volume 9 - Issue 1 p. 40- 46
Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. Inbred mice and two species of non-human primates proved to be susceptible to experimental infection with PhHV-2. The development of myoepitheliomas and spleen hyperplasia upon cyclosporin A treatment in some of the PhHV-2-infected animals warrants further investigation of the oncogenic and zoonotic potential of this virus.
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| doi.org/10.1016/j.micinf.2006.10.006, hdl.handle.net/1765/36746 | |
| Microbes and Infection: a journal on infectious agents and host defenses | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Martina, B., Verjans, G., Kuiken, T., van Amerongen, G., & Osterhaus, A. (2007). In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species. Microbes and Infection: a journal on infectious agents and host defenses, 9(1), 40–46. doi:10.1016/j.micinf.2006.10.006 |
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