The STOX1 gene, identified as a candidate gene for pre-eclampsia in Dutch women, is placentally expressed and subject to imprinting with preferential transmission of the maternal allele. In our study, STOX1-Y153H frequencies were similar in 157 women with pre-eclampsia (65%) and in 157 controls (64%) from the general Dutch population. In an isolated Dutch population, a distortion could not be demonstrated in the transmission of STOX1-Y153H variation from heterozygous mothers to offspring in 50 and 56 families with pregnancies complicated by pre-eclampsia or intrauterine growth restriction, respectively. Our findings do not confirm previous suggestions that STOX1 plays a major role in Dutch women with pre-eclampsia.

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BJOG: An International Journal of Obstetrics and Gynaecology
Erasmus MC: University Medical Center Rotterdam

Berends, A., Bertoli Avella, A., de Groot, C., Tikka-Kleemola, P., Oostra, B., & Steegers-Theunissen, R. (2007). STOX1 gene in pre-eclampsia and intrauterine growth restriction. BJOG: An International Journal of Obstetrics and Gynaecology, 114(9), 1163–1167. doi:10.1111/j.1471-0528.2007.01414.x