New insights into the underlying mechanism of Crohn's disease is enabling the development of new therapies. Even though the mechanisms of these drugs have been studied extensively, reliable indicators for implementation of new biologic drugs are still needed. This review presents biologics in Crohn's disease focusing on efficacy, steroid sparing, mucosal healing and safety, including immunogenicity.

Biologic therapy, Crohn's disease, Indicators,
Expert Opinion on Biological Therapy
Erasmus MC: University Medical Center Rotterdam

van der Woude, C.J, & Hommes, D.W.S. (2007). Biologics in Crohn's disease: Searching indicators for outcome. Expert Opinion on Biological Therapy (Vol. 7, pp. 1233–1243). doi:10.1517/14712598.7.8.1233