Objective: To explore pregnancy outcome in HIV-1-positive and HIV-negative women, and mother-to-child transmission (MTCT) according to mode of delivery under effective highly active antiretroviral therapy (HAART). Design: Cohort of 143 pregnant HIV-1-infected women including a matched case-control study in a 2:1 ratio of controls to cases (n = 98). Setting: Academic Medical Center in Amsterdam and Erasmus Medical Center in Rotterdam, the Netherlands. Population: Consecutive referred HIV-1 infected pregnant women treated with HAART and matched control not infected pregnant women. Main outcome measures: MTCT, preterm delivery, low birthweight, pre-eclampsia. Results: MTCT was 0% (95% CI 0-2.1%). Seventy-eight percent of HIV-1-infected women commenced and 62% completed vaginal delivery. The calculated number of caesarean sections needed to prevent a single MTCT was 131 or more. Preterm delivery rates were 18% (95% CI 11-27) in women infected with HIV-1 and 9% (95% CI 5-13) in controls (P = 0.03). HAART used at <13 weeks of gestation was associated with a 44% preterm delivery rate compared with 21% when HAART was started at or after 13 weeks and 14% in controls. (Very) low birthweight and incidence of pre-eclampsia were not different between HIV-1 and controls. Conclusions: We have not demonstrated any MTCT after vaginal delivery in women effectively treated by HAART. The HAART-associated increase in preterm delivery rate is mainly seen after first trimester HAART use.

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doi.org/10.1111/j.1471-0528.2006.01183.x, hdl.handle.net/1765/36942
BJOG: An International Journal of Obstetrics and Gynaecology
Erasmus MC: University Medical Center Rotterdam

Boer, K., Nellen, J., Patel, D., Timmermans, S., Tempelman, C., Wibaut, M., … Godfried, M. H. (2007). The AmRo study: Pregnancy outcome in HIV-1-infected women under effective highly active antiretroviral therapy and a policy of vaginal delivery. BJOG: An International Journal of Obstetrics and Gynaecology, 114(2), 148–155. doi:10.1111/j.1471-0528.2006.01183.x