Nicardipine in pre-eclamptic patients: Placental transfer and disposition in breast milk
BJOG: An International Journal of Obstetrics and Gynaecology , Volume 114 - Issue 2 p. 230- 233
To assess the safety risks to the fetus and neonate caused by maternal use of nicardipine in pre-eclamptic patients, we evaluated the placental transfer and the transfer to breast milk after maternal intravenous administration of nicardipine. In ten pre-eclamptic subjects, nicardipine concentrations of maternal blood (P) and both arterial and venous umbilical cord blood samples (Uarterialand Uvenous) were assessed, and the U/P ratio was calculated as an indication of placental transfer. We found a median transfer of 0.15 (Uarterial/P, range 0.05-0.22) and 0.17 (Uvenous/P, range 0.023-0.22). The highest umbilical cord concentration found after maternal dosage of 4.5 mg/hour was 18 ng/ml, which can be considered as subtherapeutic. Therefore, adverse fetal reactions caused by a direct pharmacological effect of nicardipine are unlikely to occur. Nicardipine levels were determined in 34 breast milk samples of seven women, and were found to be undetectable in 82% of the samples. In six breast milk samples of four different women, nicardipine levels (ranging from 5.1 to 18.5 ng/ml) were detectable during maternal nicardipine dosages ranging from 1 to 6.5 mg/hour. The maximum possible exposure of a neonate to nicardipine was calculated to be less than 300 ng/day, which is an insignificant fraction of therapeutic dosages used in neonates. In conclusion, the exposure of a fetus and neonate to nicardipine through placental transfer and disposition in breast milk expression is low.
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|BJOG: An International Journal of Obstetrics and Gynaecology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Bartels, P.A, Hanff, L.M, Mathot, R.A, Steegers-Theunissen, R.P.M, Vulto, A.G, & Visser, W. (2007). Nicardipine in pre-eclamptic patients: Placental transfer and disposition in breast milk. BJOG: An International Journal of Obstetrics and Gynaecology, 114(2), 230–233. doi:10.1111/j.1471-0528.2006.01200.x