Constitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated by vesicles, which bud off the trans-Golgi network, move along cytoskeletal filaments, and fuse with the plasma membrane. Here, we show that the small GTPase Rab6 marks exocytotic vesicles and, together with the microtubule plus-end-directed motor kinesin-1, stimulates their processive microtubule-based transport to the cell periphery. Furthermore, Rab6 directs targeting of secretory vesicles to plasma-membrane sites enriched in the cortical protein ELKS, a known Rab6 binding partner. Our data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space.,
Developmental Cell
Erasmus MC: University Medical Center Rotterdam

Grigoriev, I., Splinter, D., Keijzer, N., Wulf, P., Demmers, J., Ohtsuka, T., … Akhmanova, A. (2007). Rab6 Regulates Transport and Targeting of Exocytotic Carriers. Developmental Cell, 13(2), 305–314. doi:10.1016/j.devcel.2007.06.010