This thesis describes my work, where I used genetic methods to identify new genes involved in salt taste in C. elegans. In addition, I used calcium imaging to characterize the cellular response of C. elegans to salt. The thesis is divided into five sections and each section is summarized below. In chapter 1, I discuss the importance of salt for our health and subsequently our current knowledge about the different taste modalities and how their sensations are regulated in mammals and Drosophila. Next, I discuss several sensory behaviours of C. elegans and the signal transduction pathways involved, with an emphasis on salt chemotaxis. Furthermore, I discuss different types of learning and memory observed in C. elegans and neurotransmitters involved. Finally, I discuss the importance of C. elegans as a model organism and the behavioural and neuronal methods commonly employed to study C. elegans response to salt.

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The research described in this thesis was financially supported by NWO, Netherlands and the printing of this thesis was partially supported by the J.E. Jurriaanse Stichting
F.G. Grosveld (Frank)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Umuerri, O. O. (2012, September 12). Caenorhabditis elegans response to salt. Retrieved from