Respiratory disease is frequently present in childhood. It can be divided into upper airway disease and lower airway or lung disease. Two important lung diseases in childhood are cystic fibrosis (CF) and asthma. They are important because CF is the most common lethal genetic disease in the Caucasian population and asthma is one of the most frequent chronic diseases of childhood, with a prevalence of approximately 10% of children in the Western world. In both lung diseases the small airways, located in the periphery of the lung, are frequently affected. To provide optimal care for patients with lung disease it is important to accurately measure the severity of lung disease and to effectively treat the affected airways.

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The studies performed in this thesis were supported by Roche BV, Activaero GmbH, Stichting Astma Bestrijding and Stichting Vrienden van het Sophia. The print and reproduction of this thesis were kindly supported by Activaero GmbH, Astma Fonds, GlaxoSmithKline BV and Stichting Astma Bestrijding.
H.A.W.M. Tiddens (Harm)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

van den Beukel-Bakker, M. (2012, October 3). Detection and aerosol treatment of small airway disease in pediatric cystic fibrosis and asthma. Retrieved from