ADDIS: A decision support system for evidence-based medicine
Decision Support Systems , Volume 55 - Issue 2 p. 459- 475
Clinical trials are the main source of information for the efficacy and safety evaluation of medical treatments. Although they are of pivotal importance in evidence-based medicine, there is a lack of usable information systems providing data-analysis and decision support capabilities for aggregate clinical trial results. This is partly caused by unavailability (i) of trial data in a structured format suitable for re-analysis, and (ii) of a complete data model for aggregate level results. In this paper, we develop a unifying data model that enables the development of evidence-based decision support in the absence of a complete data model. We describe the supported decision processes and show how these are implemented in the open source ADDIS software. ADDIS enables semi-automated construction of meta-analyses, network meta-analyses and benefit-risk decision models, and provides visualization of all results.
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van Valkenhoef, G, Tervonen, T, Zwinkels, T, de Brock, B, & Hillege, H.L. (2013). ADDIS: A decision support system for evidence-based medicine . Decision Support Systems, 55(2), 459–475. doi:10.1016/j.dss.2012.10.005