1983-10-12
Isolation of a somatomedin binding protein from human preterm amniotic fluid : development of a radioimmunoassay
Publication
Publication
This thesis study was undertaken in order to investigate the nature and biological behavior of a somatornedin binding protein, identified in preterrn amniotic fluid (AF). Somatomedin (SM) is the generic designation applied to a family of serum peptide growth factors which are growth hormone dependent, stimulate incorporation of sulphate into cartilage, have insulin-like actions on nonskeletal tissues and increase mitosis in a wide variety of cultured cells. Thusfar two peptides have been fully characterized: insulin-like growth factor I (IGF-I), shown to be identical to sornatomedin-C, and insulin-like growth factor II (IGF-II). IGF-I and IGF-II have a 62% aminoacid sequence identity and are 38-48% homologous with the A and B domains of human pro-insulin.
Additional Metadata | |
---|---|
, , , , , | |
H.K.A. Visser (Henk) , H.J. Guyda | |
Erasmus University Rotterdam | |
hdl.handle.net/1765/37582 | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Drop, S. (1983, October 12). Isolation of a somatomedin binding protein from human preterm amniotic fluid : development of a radioimmunoassay . Retrieved from http://hdl.handle.net/1765/37582 |
Additional Files | |
---|---|
0371_Drop, Stenvert Leonard Sebastiaan.jpg Cover Image , 207kb | |
Stellingen Drop, Stenvert Leonard Sebastiaan.pdf , 72kb |