This thesis focusses on understanding the role of three transcriptions factors, namely ATF3, EGR3 and PU.1, and also microRNA-146a, involved in the activation of monocytes, macrophages and microglia in pathological conditions, which are thought to be driven – at least in part – by special inflammatory reactions. The diseases in question are severe psychiatric diseases, such as bipolar disorder, major depression, schizophrenia and postpartum psychosis and X-linked juvenile retinoschisis. In the introduction the immune cells, the diseases and the transcription factors + pathways will be introduced subsequently.

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The studies were financially supported by the European Commission EU-FP7- HEALTH-F2-2008-222963 ‘MOODINFLAME’, ZonMW-TOP-91208018, The Pro Retina Foundation Germany, the German Research Foundation (DFG) and the J.E. Jurriaanse Stichting
H.A. Drexhage (Hemmo) , T. Langmann (Thomas)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Weigelt, K. (2012, November 7). Two Sides of the Same Coin : Unravelling the role of transcription factors and miRNAs in activated monocytes, macrophages and microglia. Retrieved from