From 1991, our research group and others have been investigating children with short stature who were born small for gestational age (SGA), both before and during treatment with biosynthetic growth hormone (GH). In 2005, GH treatment was licensed for short SGA children in the Netherlands. Many questions though remained unanswered, especially about the efficacy of GH treatment when started at an older age, just before or during puberty. This doctoral thesis describes studies evaluating short adolescents born SGA who were treated with GH, and additionally with postponement of puberty by gonadotropin-releasing hormone analogue (GnRHa).

bone density, growth hormone, puberty, small for gestational age
A.C.S. Hokken-Koelega (Anita)
Erasmus MC: University Medical Center Rotterdam
The studies described in this thesis were supported by an investigator-initiated independent research grant provided by Pfizer Inc., USA. Publication of this thesis was financially supported by the Dutch Growth Research Foundation, Pfizer bv and the SGA platform
978-94-6191-447-7
hdl.handle.net/1765/37643
Erasmus MC: University Medical Center Rotterdam

Lem, A.J. (2012, November 9). Short Adolescents Born Small for Gestational Age : Gonadal and thyroid function, bone mineral density, quality of life and adult height: The effects of growth hormone and additional postponement of puberty. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/37643