In the experiments described in this thesis transmembrane transport of thyroid hormones into liver cells is investigated, in particular the regulatory role of this transport process in the bioavailability of thyroid hormones in (patho )fysiological conditions. This first chapter is an introduction to the studies described in Chapters 3-9. It opens with a short description of different aspects regarding thyroid hormones, i.e. synthesis, transport in blood to the different organs, transport into cells, nuclear binding and the different routes of intracellular metabolism. Only the main issues will be discussed here. The isolated rat liver perfusion system was used to study the transport process in most of our studies. Therefore, this perfusion system is also described in this chapter and compared to isolated rat hepatocytes in primary culture, in which many studies on thyroid hormone transport have been performed. Furthermore, a twocompartment model, which describes thyroid hormone kinetics in the liver perfusion system, is dealt with here. At the end of the chapter the scope of the thesis and a short overview of the questions that were addressed are presented

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This work was supported by grant 900-540-191 from the Netherlands Organization for Scientific Research (NWO).
E.P. Krenning (Eric) , G. Hennemann (George)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

de Jong, M. (1993, December 9). Thyroid hormone transport into liver cells: its (patho)physiological significance . Retrieved from