2012-11-28
Generation of an immunocompetent B-cell Repertoire
Publication
Publication
Het opbouwen van een immunocompetent B-cel repertoire
The immune system of higher vertebrates, such as humans, has multiple lines of defense against invading microorganisms. The first line is a physical and chemical barrier formed by the skin, mucous membranes and their secretions to prevent the entrance of microorganisms into the body.1-3 The second line consists of proteins (e.g. complement)4 and immune cells (e.g. macrophages, granulocytes, natural killer cells) which are the components of the innate immune system.5-6 Finally, the third line concerns the adaptive immune system with T and B lymphocytes specifically interacting with the invading pathogen. These cells do not only recognize pathogen with a specific antigen receptor, they also adapt their response during an infection to improve recognition of the pathogen and they generate long-term immunological memory.
| Additional Metadata | |
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| , | |
| The studies were financially supported by the Department of Immunology, Erasmus MC, Rotterdam, the Netherlands, and partly by Ter Meulen Fund - Royal Netherlands Academy of Arts and Sciences and Nestlé Nutrition | |
| J.J.M. van Dongen (Jacques) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/37956 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Berkowska, M. (2012, November 28). Generation of an immunocompetent B-cell Repertoire. Retrieved from http://hdl.handle.net/1765/37956 |
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| Additional Files | |
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| statements M. Berkowska.pdf Final Version , 511kb | |
| title page M Berkowska .pdf Final Version , 302kb | |
| 3646_Berkowska, Magdalena Agnieszka.jpg Cover Image , 39kb | |
