This doctoral thesis describes cardiovascular and metabolic risk factors in children en young adults with a small birth size, either due to being born small for gestational age (SGA) or due to prematurity. For those born SGA with persistent short stature, the short and long-term effects of growth hormone (GH) treatment on these risk factors were studied. This chapter provides definitions and gives background information on SGA and prematurity. Finally, the aims of the study, the outline of this thesis, inclusion and exclusion criteria and study design of the IUGR-1, IUGR-2 and IUGR-3 study (Appendix A-C), and the PROGRAM/PREMS study (Appendix D) are presented.

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The studies described in this thesis were supported by an investigator-initiated independent research grant provided by Novo Nordisk B.V., Pfizer Inc., Netherlands Organisation for Scientific Research (NWO), and by grants from Revolving Fund 2001; Vereniging Trustfonds, Erasmus University Rotterdam; Jan Dekkerstichting/Dr Ludgardine Bouwmanstichting; and Stichting De Drie Lichten, the Netherlands. Publication of this thesis was financially supported by the SBOH, employer of GP trainees, and the SGA platform.
A.C.S. Hokken-Koelega (Anita)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam