2012-12-19
Impact of Signaling and Plasticity on Cerebellar Function and Memory Formation
Publication
Publication
Gevolgen van Signaaloverdracht en Plasticiteit op Cerebellair Functioneren en Geheugenvorming
Although the full extent of cerebellar involvement in the many aspects of behaviour remains elusive, its role in the control of movement has been known for more than a century (Glickstein et al., 2009). Positioned as an isolated network superimposed on other structures within the brain, the cerebellum is typically regarded as a ‘controller’ of ongoing processes, such as the fine-tuning of movement and posture (Fig 1). As a controller, the output of the cerebellum needs to be flexible and constantly adapt to (re-)establish the desired level of control. It is generally believed that plasticity (i.e. the ability of a synapse to alter its connective strength) underlies the process of adaptation and embodies the structural substrate of learning and memory formation.
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| We kindly thank the Dutch Organization for Medical Sciences (ZonMw; CIDZ), Life Sciences (ALW; CIDZ, ZG, BvB), Senter (NeuroBasic; CIDZ), and the ERC-advanced, CEREBNET and C7 programs of the European Community (CIDZ) for their financial support. | |
| C.I. de Zeeuw (Chris) , C.R.W. Hansel (Christian) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/38471 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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van Beugen, B. (2012, December 19). Impact of Signaling and Plasticity on Cerebellar Function and Memory Formation. Retrieved from http://hdl.handle.net/1765/38471 |
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| Additional Files | |
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| 3656_Beugen, Boeke Job van.jpg Cover Image , 87kb | |
| Stellingen Beugen, Boeke Job van.pdf , 22kb | |
