This thesis deals with the differentiation and maturation ofT (thymusderived) lymphocytes. The development of mature immunocompetent T lymphocytes requires 3 steps. Firstly, HSC differentiate to prothymocytes, precursors committed to the T cell lineage. These cells leave the BM and settle in the thymus. Secondly, upon entry into the thymus, these prothymocytes proliferate and give rise to a population of immature thymocytes (thymic lymphocytes). Thirdly, thymocytes differentiate into mature T eel ls that emigrate from the thymus to peripheral lymphoid organs. After activation by antigen these mature T ~ells function as effector eel ls in the cellular immune response, and as regulatory cells in both the humoral and the cellular immune response (Cantor and Weissman, 1976; Stutman, 1978). This thesis deals mainly with intrathymic events in T eel l differentiation. A summary of current knowledge ofT eel 1 differentiation is given in Chapter 2.

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O. Vos
Erasmus University Rotterdam
Het onderzoek werd mede mogelijk gemaakt door linanciele steun van de Stichting voor Medisch Wetenschappelijk Onderzoek FUNGO van de Nederlandse Organisatie voor Zuiver Wetenschappelijk Onderzoek
Erasmus MC: University Medical Center Rotterdam

van Vliet, P.W. (1985, September 11). Stromal cells in the mouse thymus : an immunocytochemical characterization of the thymic microenvironment. Erasmus University Rotterdam. Retrieved from