2012-12-14
Induction of immunoglobulin A as a therapeutic intervention in allergic asthma
Publication
Publication
Stimuleren van immunoglobuline A als therapeutische interventie tegen allergisch astma
Allergic asthma is a chronic inflammatory disorder of the airways in response to inhaled allergens and is characterized by airway inflammation, bronchial hyperresponsiveness and a variable degree of airflow obstruction, leading to episodes of wheezing, coughing and breathlessness. In addition, structural changes (‘airway remodeling’) in the airway including subepithelial and airway wall fibrosis, goblet cell hyperplasia/metaplasia, smooth muscle thickening and increased vascularity are observed. In susceptible individuals, repeated exposure to harmless environmental allergens like house-dust mites (HDMs), molds, plant pollen and animal dander can lead to sensitization and development of a chronic immune response consisting of an effector cascade leading to immediate and late-phase reactions to allergens and subsequent characteristic clinical symptoms.
| Additional Metadata | |
|---|---|
| , | |
| Dutch Asthma Foundation, J.E. Jurriaanse Stichting, Stichting Astma Bestrijding | |
| B.N.M. Lambrecht (Bart) , R.W. Hendriks (Rudi) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/38702 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Gloudemans, A. (2012, December 14). Induction of immunoglobulin A as a therapeutic intervention in allergic asthma . Retrieved from http://hdl.handle.net/1765/38702 |
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| Additional Files | |
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| 3664_Gloudemans, Anouk Katlijn.jpg Cover Image , 46kb | |
| stellingen Gloudemans.pdf , 36kb | |
