We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10-13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10-15; OR = 1.50).

Additional Metadata
Keywords RAD51B gene, article, binding site, breast cancer, breast epithelium, cancer risk, controlled study, effect size, female, gene, gene identification, gene locus, genetic association, genetic variability, genotype, human, major clinical study, male, priority journal, risk assessment, sex difference, single nucleotide polymorphism, tumor suppressor gene
Persistent URL dx.doi.org/10.1038/ng.2417, hdl.handle.net/1765/38813
Journal Nature Genetics
Citation
Orr, N, Lemnrau, A, Cook, P.R, Fletcher, O, Tomczyk, K, Jones, M, … Swerdlow, A.J. (2012). Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Nature Genetics, 44(11), 1–3. doi:10.1038/ng.2417