Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Orr, Nick; Lemnrau, Alina; Cook, Peter; Fletcher, Olivia; Tomczyk, Katarzyna; Jones, Marta; Johnson, Nichola; Lord, Christopher; Mitsopoulos, Costas; Zvelebil, Marketa; McDade, Simon; Buck, Gemma; Blancher, Christine; Trainer, Alison; James, Paul; Bojesen, Stig; Bokmand, Susanne; Nevanlinna, Heli; Mattson, Johanna; Friedman, Eitan; Laitman, Yael; Palli, Domenico; Masala, Giovanna; Zanna, Ines; Ottini, Laura; Giannini, Giuseppe; Hollestelle, Antoinette; van den Ouweland, Ans; Novaković, Srdjan; Krajc, Mateja; Gago-Dominguez, Manuela; Castelao, Jose; Olsson, H.; Hedenfalk, Ingrid; Easton, Douglas; Pharoah, Paul; Dunning, Alison; Bishop, David Timothy; Neuhausen, Susan; Steele, Linda; Houlston, Richard; García-Closas, Montserrat; Ashworth, Alan; Swerdlow, Anthony

doi:10.1038/ng.2417

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10-13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10-15; OR = 1.50).

Additional Metadata
Keywords	RAD51B gene, article, binding site, breast cancer, breast epithelium, cancer risk, controlled study, effect size, female, gene, gene identification, gene locus, genetic association, genetic variability, genotype, human, major clinical study, male, priority journal, risk assessment, sex difference, single nucleotide polymorphism, tumor suppressor gene
Persistent URL	doi.org/10.1038/ng.2417, hdl.handle.net/1765/38813
Journal	Nature Genetics
Organisation	Erasmus MC: University Medical Center Rotterdam
Citation APA APA Style APA-ALL Style AAA Style Cell Style Chicago Style Harvard Style IEEE Style MLA Style Nature Style Vancouver Style American-Institute-of-Physics Style Council-of-Science-Editors Style BibTex Format Endnote Format RIS Format CSL Format DOIs only Format	Orr, N., Lemnrau, A., Cook, P., Fletcher, O., Tomczyk, K., Jones, M., Johnson, N., Lord, C., Mitsopoulos, C., Zvelebil, M., McDade, S., Buck, G., Blancher, C., Trainer, A., James, P., Bojesen, S., Bokmand, S., Nevanlinna, H., Mattson, J., … Swerdlow, A. (2012). Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Nature Genetics, 44(11), 1–3.https://doi.org/10.1038/ng.2417

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

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Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

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