Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis, with MICs ranging from≤0.016 to 0.125 μg/ml. Due to its favorable pharmacokinetics, isavuconazole could be a promising antifungal agent in the treatment of mycetoma. Copyright

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doi.org/10.1128/AAC.01170-12, hdl.handle.net/1765/38852
Antimicrobial Agents and Chemotherapy
Erasmus MC: University Medical Center Rotterdam

Kloezen, W., Meis, J., Curfs-Breuker, I., Fahal, A., & van de Sande, W. (2012). In vitro antifungal activity of isavuconazole against Madurella mycetomatis. Antimicrobial Agents and Chemotherapy, 56(11), 6054–6056. doi:10.1128/AAC.01170-12