2012-11-14
The Role of ZBP-89 in Globin Regulation
Publication
Publication
De rol van ZBP‐89 in de regulatie van globine
The ameliorating effect of increased γ‐globin gene expression in β‐thalassemia and Sickle cell disease, favored γ‐globin gene reactivation as the most attractive treatment approach. This has led to intense research efforts to elucidate the mechanism of γ‐globin gene switching with the aim of reversing the switching process. Many DNA cis elements (e.g. LCR, ‐117 HPFH mutation, BGL3 region) as well as trans regulatory protein such as BCL11a, LDB1, and KLF1 has been identified that are important for developmental globin genes regulation. This and other evidences from literature suggest the involvement of other protein factors, as yet unknown, on γ‐globin promoter or LCR that work remotely with previously known protein factors. We recently described an unbiased proteomics approach; Targeted Chromatin Purification (TChP), to identify other possible proteins involved in γ‐globin silencing. ZBP‐89 was identified as one of the proteins in γ‐globin chromatin purification. Here we report functional study on the role of ZBP‐89 in globin regulation.
| Additional Metadata | |
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| , | |
| F.G. Grosveld (Frank) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/38918 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Aghajanirefah, A. (2012, November 14). The Role of ZBP-89 in Globin Regulation. Retrieved from http://hdl.handle.net/1765/38918 |
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