This review presents an overview of the most important rodent-borne hemorrhagic fever pathogens directly transmitted from rodents to humans, namely Leptospira and hantaviruses, together with the New-and Old-World arenaviruses. These zoonotic diseases frequently share clinical symptoms, transmission routes and other epidemiological features and often have an emerging pattern. Differential diagnostics could benefit from a syndrome-based approach grouping these pathogens. In this review extensive descriptions of the epidemiology, clinical symptoms, diagnostics and treatment are provided including a practical overview, listing clinical features, diagnostics and risk factors for each selected rodent-borne hemorrhagic fever pathogen.

Hantavirus, Lassa fever, Leptospirosis, Rodent-borne diseases, South-american haemmorrhagic fever
dx.doi.org/10.3109/1040841X.2012.686481, hdl.handle.net/1765/38973
Critical Reviews in Microbiology
This work was funded by the European Commission 7th Framework Programme; grant id fp7/261504 - Biology and control of vector-borne infections in Europe (EDENEXT)
Erasmus MC: University Medical Center Rotterdam

Goeijenbier, M, Wagenaar, J.F.P, Goris, M.G.A, Martina, B.E.E, Henttonen, H, Vaheri, A, … van Gorp, E.C.M. (2013). Rodent-borne hemorrhagic fevers: Under-recognized, widely spread and preventable-epidemiology, diagnostics and treatment. Critical Reviews in Microbiology (Vol. 39, pp. 26–42). doi:10.3109/1040841X.2012.686481